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Pyroluria (anxiety, severe inner tension disorder)
PYROLURIA Pyroluria is a genetically determined chemical imbalance involving an abnormality in hemoglobin synthesis. Hemoglobin is the protein that holds iron in the red blood cell. Individuals with this disorder produce too much of a byproduct of hemoglobin synthesis called "kryptopyrrole" (KP) or "hemepyrrole." Kryptopyrrole has no known function in the body, and is excreted in urine.

Kryptopyrrole has binds to pyridoxine (vitamin B6) and zinc and makes them unavailable for their important roles of co-factors in enzymes and metabolism.

The effect of pyroluria can have a mild, moderate, or severe depending on the severity of the imbalance. Most individuals show symptoms of zinc and/or B6 deficiencies, which include:

* poor stress control
* nervousness,
* anxiety,
* mood swings,
* severe inner tension,
* episodic anger (an explosive temper),
* poor short-term memory and depression.

Often pyrolurics may:

* have pale skin that easily burns,
* eyes that are sensitive to light,
* white flecks/marks on their nails,
* stretch marks on their skin,
* tire easily,
* be anemic,
* have poor dream recall,
* prefer not to eat breakfast,
* notice upper abdominal pain when stressed,
* experience a "stitch" in their side if they run,
* have poor dream recall,
* and have a tendency to become loners as they age.

Mental symptoms are aggravated when undergoing stress. In fact, pyroluria flares up when the individual is undergoing prolonged stress, such as during a chronic and debilitating illness.

Pyroluria may occur along with other imbalances as seen in some subtypes of schizophrenia such as histapenia (low histamine), histadelia (high histamine), high copper levels or cerebral allergies. It is the primary imbalance for 20% of schizophrenics.

Alcohol use is one way for pyrolurics to shut off their anxiety, feel more sociable, de-stress, and experience a short time when they feel more normal. Without a knowledge of this chemical imbalance, those who try to quit alcohol use must face coexisting with their symptoms.

Most pyrolurics exhibit at least two of these problems. These individuals cannot efficiently create serotonin (a neurotransmitter that reduces anxiety and depression) since vitamin B6 is an important factor in the last step of its synthesis.

Many of these persons appear to benefit from SSRI medications such as Prozac, Paxil, Zoloft, Celexa, etc. However, as with all mind-altering drugs, side effects occur and the true cause of the mental difficulties remains uncorrected. In addition these individuals often have frequent infections and are often identified by their inability to tan, poor dream recall, abnormal fat distribution, and sensitivity to light and sound. As you can imagine an SSRI will not correct these metabolic effects. More healthful benefits may be achieved by giving the appropriate supporting nutrients.

Pyroluria is detected by chemical analysis of the abnormal pyroles in urine. The test costs 30.00.

People with mild-moderate pyroluria usually have a fairly rapid response to treatment if no other chemical imbalances are present. People with severe pyroluria usually require several weeks before progress is seen and improvement may be gradual over 3 - 12 months. Features of pyroluria usually recur within 2 - 4 weeks if the nutritional program is stopped.

Carole can help you manage your pyroluria by restoring vitamin B6 and zinc. The type of replacement therapy is very important as zinc must be provided in an efficiently absorbed form. Vitamin B6 is also available in several forms. Both zinc and B6 supplementation need to be directed by Carole as too much can be toxic, use of the wrong form will be ineffective, and avoiding competing minerals and supplements may be necessary. Other nutrients may assist in pyroluria include niacinamide, pantothenic acid, manganese, vitamins C and E, omega-6 fatty acids and cysteine. Food sources and nutritional supplements containing copper and red/yellow food dyes should be avoided.

Please note that it is extremely important to obtain an accurate diagnosis before trying to find a cure. Many diseases and conditions share common symptoms: if you treat yourself for the wrong illness or a specific symptom of a complex disease, you may delay legitimate treatment of a serious underlying problem. In other words, the greatest danger in self-treatment may be self-diagnosis. If you do not know what you really have, you can not treat it!

It can not be stressed enough that there is no single diet or nutritional agent that fits everyone. Your biochemical individuality must be taken into account. Carole will help you do this, many of her patients now live happy, harmonious lives after suffering from severe anxiety and unhappiness for many years.


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